Officers raided the Irma Lane home shortly after midnight March 23 and arrested Ryan Lacko, 39, and Bonnie Skinner, 45, both of Olmsted Township, police said.
The couple is charged with endangering children, manufacturing a controlled substance and possession of a controlled substance.
Their cases have been bound over to a Cuyahoga County grand jury.
Three girls living in the mobile home — ages 12, 14 and 16 — were turned over to their grandparents, police said.
Officers began investigating the mobile home after receiving an anonymous tip, Olmsted Township Police Lt. Matt Vanyo said.
“Once we found out there were three children in the home, we wasted no time (preparing for the raid)” he said.
Lacko and Skinner were arrested without incident and officers found evidence that they were cooking methamphetamine, Vanyo said.
The Ohio Bureau of Criminal Investigation and the Ohio Highway Patrol assisted in the raid, Vanyo said.
The ingredients to methamphetamine are potentially explosive and the Highway Patrol has troopers trained to safely raid and break down suspected labs.